OyaGen News

COVID-19 News 

New Publication in JCI Insight 11-22-21: Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties

Tonix Press Release  11-22-21: Tonix Pharmaceuticals Announces Publication of Paper on Antiviral SARSCoV-2 Inhibitor, TNX-3500, in JCI Insight 

Tonix OyaGen AgreementTonix Pharmaceuticals Enters into Exclusive Worldwide Licensing Agreement with OyaGen to Develop Antiviral SARS-CoV-2 Inhibitor, TNX-3500, for the Treatment of COVID-19 

Dr. James Cummings Joins OyaGen Board of Directors: Will provide expertise on OyaGen’s lead antivirals for Covid 2, HIV and Ebola

WHAM 13 ABC – 1-13-21: ROC company reports breakthroughs in drug to treat COVID; focus remains on vaccine

OYA1 “HIGHLY EFFECTIVE” 1-07-21: Press Release, A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures

Genetic Engineering and Biology News: Catching Up to Coronavirus: Top 60 Treatments in Development 

Genetic Engineering and Biology News: Vanquishing the Virus: 160+ COVID-19 Drug and Vaccine Candidates in Development

Podcast: Our Body’s Response and Drug Development Policies in the Year of Corona – Harold Smith interviewed on Steve’s Cannabis Show, April 2, 2020.

Press Release: OyaGen, Inc. announces a compound in development with broad antiviral activity against coronaviruses including SARS-CoV-2

Daily Kos – ROC biotech company says lab tests of former cancer drug confirm it stops COVID-19

WHAM13 ABCROC biotech company says lab tests of former cancer drug confirm it stops COVID-19

Spectrum NewsOyaGen Lab Discovers Compound They Believe Could Help With COVID-19


Opinion: Is A Cure for HIV/AIDS Possible?

Salter, J.D. & Smith, H.C. (2018) Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligand. Trends in Biochemical Sciences. In press

Bennett, R.P., Salter, J.D., Smith, H.C. (2018) A New Class of Antiretroviral Enabling Innate Immunity by Protecting APOBEC3 from HIV Vif-Dependent Degradation. Trends in Molecular Medicine Published online March 30, 2018  PMID:29609878. Review

Polevoda, B., Joseph, R., Friedman, A.E., Bennett, R.P., Greiner, R., De Zoysa, T., Stewart, R.A., Smith, H.C. (2017) DNA Mutagenic Activity and Capacity for HIV-1 Restriction of the Cytidine Deaminase APOBEC3G Depends on Whether DNA or RNA Binds to Tyrosine 315. J. Biol. Chem., 292:8642-56.

Smith, H.C. (2017) RNA Binding to APOBEC Deaminases, Not Simply a Substrate for C to U Editing.RNA Biol. 14:1153-65.

Hilimire, T.A., Chamberlain, J.M., Anokhina. V, Bennett, R.P., Swart, O., Myers, J.R., Ashton, J.M., Stewart, R.A., Featherstone. A.L., Gates, K., Helms, E.D, Smith, H.C. Dewhurst, S., Miller, B.J. (2017) HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells. ACS Chem. Biol. 12:1674-82.

Bennett, R.P., Stewart, R.A., Hogan, P., Ptak, R.G., Mankowski, M.K., Hartman, T.L., Buckheit, R.W., Jr., Snyder, B.A., Salter, J.D., Morales, G.A., Smith, H.C. (2016) An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation. Antiviral Research 136:51-9  PMID:27825797

Salter, J.D., Bennett, R.P., Polevoda, B. and Smith, H.C. (2016) The APOBEC Protein Family United by Structure, Divergent in Function. Trends in Biochemical Sciences, Cell Press. 41:578-94 PMID:27283515

World AIDS Day Feature, aired December 3, 2015, Rochester Channel 8 News –  Local biotech company finds HIV/AIDS breakthrough: OyaGen Inc. working towards clinical trials

World AIDS Day Feature, aired November 30, 2015 –  Henrietta Medical Research Firm Working Toward HIV/AIDS Breakthrough

A&U America’s AIDS Magazine, October, 2015 – Talking “Cure”: What are the barriers to cure research?  Part 1 of an interview with Dr. Harold Smith

A&U America’s AIDS Magazine, December 4, 2015 – High Bar: Have we limited cure research by approaching it through a treatment paradigm?   Part 2 of an interview with Dr. Harold Smith

Profile in Adjacent Government, November 12, 2015 – Are we standing in our own way on the path to a cure for HIV /AIDS?

Smith HC, (2015) Starting Biotech from Scratch International Innovation. 185:82-85.

July 22-23, 2015 – OyaGen focuses on biotech entrepreurism for small and medium size business in panel discussion for USA Kenya Trade Direct Business Forum

November 13, 2013 – U.S. Congresswoman Louise Slaughter visits OyaGen

October 2013 – Oyagen, Inc receives a third NIH grant as an R01 for the development of
methods for high throughput screening for compounds that prevent the cellular protein known as CBF beta from binding to and stabilizing the HIV Vif protein. Antagonist of
this interaction will prevent Vif from attacking our innate defense against HIV known as APOBEC.

October 15, 2013 – OyaGen Board Members speak at Senate Majority Coalition Public Forum on Regulatory Reform – Biotechnology, Rochester, NY
Video coverage

September 16, 2013 – New York State Comptroller Thomas DiNapoli visits OyaGen
Photos and storyVideo coverage

July 12, 2013 – Assemblyman Harry B. Bronson visits OyaGen

June 11, 2013 – OyaGen Appoints Former Assistant U.S. Surgeon General to Board of Directors

June 6, 2013 – Senator Michael H. Ranzenhofer’s visit to OyaGen

News video featuring OyaGen – Biotech at the Rochester BioVenture Center

May 21, 2013 in the Strategic Health Resources LLC, Biotechnology Blog:
Fighting the Enemy at the Gates: A Small Biotech Company Battles to Provide New HIV Solutions as Long Term HIV Survivors Run Out Of Time

January 25, 2013 in HIV & HCV Haven:
Getting to the HAART of the matter: APOBECE3G A new target to cripple HIV

Oyagen, Inc receives a second NIH R21 grant for high throughput screening for compounds that activate the antiviral host defense activity of APOBEC3G entitled Development of a Novel HIV/AIDS Theraputic Activating the APOBEC3G Host Defense.

BluPrint Fund Award for Economic Development in UpState NY
Rochester, NY – Rochester Business Journal, January 8, 2010

Coverage of New York State Pension Fund Investment in OyaGen – September, 2010

State pension fund invests in Henrietta biotech firm
Rochester, NY – Democrat and Chronicle
OyaGen gets $500,000 from state retirement fund
Rochester, NY – Rochester Business Journal
Biotech Awarded Drug Discovery Grant
Rochester, NY – Channel 13 WOKR


Oyagen, Inc receives an NIH R21 grant for high throughput screening for compounds acting as Vif antagonist through the program announcement PAR08-024 Roadmap Molecular Libraries Initiative,  entitled Development of a High Throughput Screen for Antagonists of Vif Dimerization.

Will health reform be shot in arm for biotech firms?
Rochester, NY –  Democrat & Chronicle, April 2, 2010

OyaGen’s founder and CSO receives a Bill and Melinda Gates Foundation Award for his academic research.
Rochester, NY – URMC Press Release – October, 2009

Rochester, NY Named One of the Top 20 Tech Cities in the Country
Rochester, NY –  Greater Rochester Enterprise advertisement, 2005

OyaGen blazing path toward anti-AIDS drug
Rochester, NY – Democrat & Chronicle, September 1, 2005

Study Holds Promise For New Way To Fight HIV
Rochester, NY  – UR Press Release – September 1, 2005

OyaGen Scientific Advisor Board Meeting – photo
New York, NY – April, 2005

Television Interview with Dr
. Smith

Rochester, NY  – R News, Cable Channel 9, January, 2004

OyaGen Channel 13 Interview
Rochester, NY  – WOKR13.TV – News Source 13, January, 2004

Rochester Start-Up Offers Groundbreaking Discovery in HIV Research
Rochester, NY – OyaGen Company Press Release

UR Invests in Anti-HIV Startup
Rochester, NY – Democrat & Chronicle, January 12, 2004


Publications from OyaGen

Smith HC, (2015) Starting Up the Road to Invention. International Innovation. 185:82-85.

Salter JD, Morales GA, Smith HC (2014) Structural insights for HIV-1 therapeutic strategies targeting Vif Trends in Biochemical Sciences September 2014. doi: 10.1016/j.tibs.2014.07.001

Mariel Selbovitz & OyaGen Community Access Board Member David Miller (2014)
The Deeper End of the Ocean: Host restrictive factors create research excitement.
A&U: America’s Aids Magazine 23 (232). p. 52

Prohaska K, Bennett RP, Salter JD, Smith HC (2014) The multifaceted roles of RNA binding in APOBEC cytidine deaminase functionsWIREs RNA 2014. doi: 10.1002/wrna.1226

Smith HC (2013) Curing Academic/Industry Ills: A National Biotech Policy Might Be the Best Solution. Genetic Engineering & Biotechnology News, November 15, 2013, 33:20

Smith HC (2011) APOBEC3G: a double agent in defense. Trends in Biochemical Sciences 2011, 36:5, pp. 239-244

Miller JH, Presnyak V, Smith HC (2007) The dimerization domain of HIV-1 viral infectivity factor Vif is required to block APOBEC3G incorporation with virions. Retrovirology 2007, 4:81