The People of OyaGen
Dr. Jason Salter, Senior Scientist
Jason Salter joined OyaGen in 2013. Dr. Salter earned his BS in Chemistry and Biology from SUNY College at Brockport in 2002 and his PhD in Biochemistry from the Department of Biochemistry and Biophysics at the University of Rochester in 2010. His research was supported by a National Institute of Health Training Grant Fellowship from 2006 – 2009. In 2009, he received best poster awards at both the Pittsburgh Diffraction Conference and the Center for AIDS Research World AIDS Day Symposium. His graduate research focused on the biophysical and structural characterization of HIV-1 auxiliary protein, viral infectivity factor (Vif) and the human antiretroviral cytidine deaminase, APOBEC3G, under the guidance of Professor Joseph E. Wedekind. At OyaGen, Jason is characterizing the interaction of HTS-identified small molecules with purified target proteins and protein complexes using a variety of biophysical methods.
Salter JD, Morales GA, Smith HC (2014) Structural insights for HIV-1 therapeutic strategies targeting Vif Trends in Biochemical Sciences September 2014. doi: 10.1016/j.tibs.2014.07.001
Salter, J. D., Lippa, G. M., Belashov, I. A., and Wedekind, J. E. (2012). Core-binding factor β (CBFβ) increases the affinity between HIV-1 Vif and Cullin 5 within an E3 Ligase Complex. Biochemistry 51, 8702-8704.
Salter, J. D., Krucinska, J., Raina, J., Smith, H. C., and Wedekind, J. E. (2009). A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function. Biochemistry 48, 10685-10687.
Bennett, R.P., Salter, J.D., Liu, X., Wedekind, J.E., Smith, H.C. (2008) APOBEC3G subunits self-associate via the C-terminal deaminase domain. J Biol Chem. 283, 33329-36.
MacElrevey, C., Salter, J.D., Krucinska, J., Wedekind, J.E. (2008) Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme. RNA. 14, 1600-1616.
Hoffman, D.L., Salter, J.D. and Brookes, P.S. (2007) Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. Am J Physiol Heart Circ Physiol. 292, H101-8.
Wedekind J. E., Gillilan, R., Janda, A., Krucinska, J., Salter, J.D., Bennett, R.P., Raina, J., Smith, H.C. (2006) Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits. J Biol Chem. 281, 38122-6.
Gunter, K.K., Aschner, M., Miller, L.M., Eliseev, R., Salter, J., Anderson, K. and Gunter, T.E. (2006) Determining the oxidation states of manganese in NT2 cells and cultured astrocytes. Neurobiol. Aging. 27, 1816-26.
Salter, J., Krucinska, J., Alam, S., Grum-Tokars, V. and Wedekind, J.E. (2006) Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer. Biochemistry. 45, 686-700.
Gunter K.K., Aschner, M., Miller, L.M., Eliseev, R., Salter J., Anderson K., Hammond S. and Gunter T.E. (2005) Determining the oxidation states of manganese in PC12 and nerve growth factor-induced PC12 cells. Free Radic. Biol. Med. 39, 164-181.
Gunter T.E., Yule, D.I., Gunter, K.K., Eliseev, R.A. and Salter, J.D. (2004) Calcium and Mitochondria. FEBS Lett. 567, 96-102.
Gunter. T.E., Miller, L.M., Gavin, C.E., Eliseev, R., Salter, J., Buntinas, L., Alexandrov, A., Hammond, S. and Gunter, K.K.. (2004) Determination of the oxidation states of manganese in brain, liver, and heart mitochondria. J. Neurochem. 88, 266-280.
Hoffmann, M.M. & Salter, J.D. (2004) Measuring P-V-T Phase Behavior with a Variable Volume View Cell. Journal of Chemical Education 81, 411-413.
Eliseev, R.A., Salter, J.D., Gunter, K.K., Gunter, T.E. (2003) Bcl-2 and tBid proteins counter-regulate mitochondrial potassium transport. Biochim. Biophys. Acta. 1604, 1-5.